Speakers: Jagath Junutula (Cellerant), Andy Polson (Genentech) , Toni Kline (Sutro), Chetana Rao (BMS), Donglu Zhang (Genentech), Keyang Xu, PhD (Genentech), Melissa Schutten (Genentech)
Organizers: Thomas Pillow (Genentech), Jack Sadowsky (Genentech)
Date: 9/12/2018
Time: 8:45-16:00
Registration fee (USD): Regular: $195; For unemployed or students: $30; Academic: $125; For major-sponsor rep (incl lunch): $0; For vendor-show rep: $35;
Location: SF Bay Area: Foster City Crowne Plaza
Major Sponsor: (2)Applied BioMath, LLC; Intertek
Vendor show vendors registered to date: (15)Alturas Analytics; Averica Discovery Services; Bruker; JOINN Labs; MabPlex; MicroConstants; Pacific BioLabs; PHARMout Laboratories; Promega; Q2 Solutions; SCIEX; Shimadzu Scientific Instruments, Inc; Sigma Aldrich; SRI International; WuXi AppTec
Registration: https://www.PBSS.org
Registration deadline:9/10/2018  (it will close sooner if the seating cap is reached)

About the Topic

Linking a small-molecule cytotoxic drug to a monoclonal antibody takes the strengths of both while potentially mitigating the liabilities. The resulting bioconjugates, known as antibody−drug conjugates or ADCs, have been validated clinically, with four approved anti-cancer agents for solid and hematological cancers. This workshop will broadly discuss the strategies for designing, constructing and analyzing ADCs utilizing the latest advances in the field.

This workshop will cover the following specific topics:

• Overview of antibody-drug conjugates (ADCs) and clinical progress
• Selecting a target for ADCs
• The chemistry of linkers and drugs
• Site-specific conjugation
• Analytical characterization of ADCs
• ADC bioanalysis & pharmacokinetics
• Preclinical safety/toxicology