Alejandro Corvalan, MD, is Principal Investigator at the Advanced Center for Chronic Diseases in Santiago, Chile.

From Dr. Corvalan\’s LinkedIn profile:

My laboratory is involved in translational cancer research at basic, clinical and population levels. My research is primarily focused on cancer epigenetics with an emphasis on the discovery and validation of tumor suppressor genes inactivated by DNA methylation and/or microRNAs. These discoveries act as potential biomarkers for the early diagnosis of cancer, monitoring treatment response and developing new treatments. Through this research, we are developing a novel screening and triage test for the early detection of gastric cancer based on cell free DNA in plasma (NCT01774266) . I am also investigating the role of two p53-dependant tumor suppresor genes, Reprimo (RPRM) and p73, in the pathogenesis of gastric cancer. In addition to this, I have strong interest in cancer systems biology, specifically exploring cancer heterogeneity through a data-mining approach by using existing databases and open-source / in-house bioinformatic softwares.