A thoughtful exploration of the clinical evidence necessary to drive the widespread uptake of mobile health solutions will be the focus of the first annual Scripps Health Digital Medicine conference. Currently there is a paucity of clinical trial data investigating the role of mobile health, although this evidence is critically necessary if it is to achieve its potential to transform care. There is a clear need for a forum to present, discuss and debate clinical trial evidence and how to best obtain it in order to accelerate change. This one-of-its-kind, interactive conference will be led by a faculty composed of leaders in this burgeoning field with a mix of developers, investigators and providers. The principal goal of the conference is to jump-start efforts to drive the widespread incorporation of evidence-based mobile health solutions for more-personalized, individual-centric care to improve outcomes, advance satisfaction and decrease costs.